janettemailo

Janette Mailo

University of Alberta

Centre Leader

Biography

Our research group focuses on neonates and children with brain injuries. Our specific interests are perinatal stroke and brain injuries in neonates with critical congenital heart diseases. Our studies include understanding of the timing and mechanism of brain injuries in order to develop early biomarkers allowing for prevention and early detection of brain injuries and stroke in neonates at risk. Our research involves basic science techniques as well as clinical research projects. Our animal models are helping us to understand pathophysiological mechanisms of brain injuries in neonates, as well as develop strategies to minimize the effect of the primary insult and prevent secondary brain injury. In the basic science lab as well as through clinical research projects we are also studying how seizures affect short term and long-term outcome after brain injury in neonates and children. Neonates with critical congenital heart diseases in particular have a significant risk of sustaining brain injury during their acute illness. In this context, our clinical work focuses on the development of neuromonitoring techniques for early identification of changes in the cerebral flow and cerebral perfusion, as well as cerebral function in neonates and children at risk.

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