Infections in children are still a major cause of early morbidity and mortality throughout the world, despite the advances made in preventive care. Infections are often a reason for children to become critically ill, and often occur in the critically ill child. My research focuses upon stemming this burden through optimizing their management in a variety of settings. Additionally, the ability of various settings and healthcare systems to cost-effectively manage critically ill children, especially those with infection, is an area of focus.